Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver
نویسندگان
چکیده
منابع مشابه
Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver.
Methyl tertiary butyl ether (MTBE) is an additive in some formulations of unleaded gasoline (UG) that enhances octane and reduces carbon monoxide emissions from motor vehicles. MTBE in CD-1 mice and UG in B6C3F1 mice increased the incidence of liver tumors selectively in female mice in their chronic bioassays. Both agents were negative in in vitro tests of genotoxicity, and exhibit similar hepa...
متن کاملThe Effects of Mtbe (Methyl Tertiary Butyl Ether) on Mouse Lung
Purpose: The study of MTBE as one of addetive substance to gasoline composition is important. on the other hand lack of sufficient and precedents from it’s application on organisms, we have tried to study the effects of its in two gavage and respiratory methods on lung structure. Materials and Methods: Experiments have done on four mice groups: A: control, B: solvent, C: gavage, D: respiratory...
متن کاملNo Promoting Effect of Ethyl Tertiary-butyl Ether (ETBE) on Rat Urinary Bladder Carcinogenesis Initiated with N-Butyl-N-(4-hydroxybutyl)nitrosamine
The effects of ethyl tertiary-butyl ether (ETBE) on two-stage urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were investigated at various dose levels with regard to possible promoting activity. Groups of 30 rats were given drinking water containing 500 ppm BBN, as an initiator, for 4 weeks and starting one week thereafter received ETB...
متن کاملToxicity of methyl tertiary-butyl ether on human blood lymphocytes.
Methyl tertiary-butyl ether (MTBE) is a synthetic solvent widely used as oxygenate in unleaded gasoline. Few studies have addressed the cellular toxicity of MTBE on some cell lines, and so far, no comprehensive study has been conducted to investigate the probable immunotoxicity of this compound. In this study, the toxicity of MTBE on human blood lymphocytes was evaluated. Blood lymphocytes were...
متن کاملHealth Effects of Exposure to Methyl Tertiary Butyl Ether (MTBE)
Methyl tertiary butyl ether (MTBE) (CAS No. 1634-04-4) is a volatile organic compound used almost exclusively as an oxygenate in unleaded gasoline to improve combustion efficiency. In the past it also had limited use as a therapeutic drug for dissolving cholesterol gallbladder stones. Currently, MTBE is added at 11% by volume to almost all of the gasoline used in California, although on March 2...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1996
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/17.12.2753